Protection from Oxidative Stress in the Cardiac H9c2-Cell.
Doxorubicin (Dox) is one of the most potent anti-neoplastic agents approved by the Food and Drug Administration. Its efficacy, however, is limited due to its well-documented cardiotoxic side effect. Since the first observation of this dosage-dependent side effect, the mechanisms and events leading to cardiotoxicity following exposure to doxorubicin have received much attention.
MicroRNAs (miRs) are a group of short non-coding RNAs, on average 22 nucleotides in length, that form an important axis of post-transcriptional regulation of gene expression. They have been identified as major modulators of all biological processes including development, cell differentiation, growth and apoptosis as well as diseases such as cancer, diabetes and cardiovascular disease (CVD).
Glycogen turnover in heart-derived H9c2 cells: Creator: Cheung, Kevin K.Y. Date Issued: 2005: Description: 5'-AMP activated protein kinase (AMPK) plays a central role in modulating the energy metabolism in the heart when the heart is under metabolic stress. In theory, AMPK activation should decrease glycogen synthesis and enhance its degradation. Thus, we determined the effect of AMPK.
Docosahexaenoic Acid Induced Apoptosis In H9c2 Cells A nd Changed Cardiac Function After Ischemia-Reperfusion Injury. by. Rawabi Soheil Qadhi. A thesis submitted to the Faculty of Graduate Studies and Research. in partial fulfillment of the requirements for the degree of. Master of Science. in. Pharmaceutical Sciences.
Isoflurane reduces endotoin-induced h9c2 cardiomyocyte injury 3977 The anesthetic isoflurane (ISO) confers an-ti-inflammatory effects by reducing the release of inflammatory mediators of stimulated mononu- clear cells in vitro15 and during LPS-induced ex-perimental endotoxemia 16,17. Hofstetter et in vivo al18 found that even a brief exposure to ISO could considerably reduce the levels of.
The present study has shown that pre-incubation with UA produces a transient increase in the mitochondrial membrane potential in H9c2 cells, which was accompanied by increases in mitochondrial reactive oxygen species (ROS) production. Studies using an antioxidant (dimethylthiourea) indicated that the suppression of mitochondrial ROS completely abrogated the UA-induced enhancement of.
Type: Master's thesis Year: 2010 Downloads: 78 Quote: 0 Read: Download Dissertation. Abstract. ObjectiveH9c2 rat myoblast cells were treated with hypoxia and reoxygenation as a simulation of myocardial ischemia-reperfusion injury model in vitro, which is respectively devided into three parts:Part One:effects of diversed lidocaine pretreatment on H9c2 cardiomyocytes against hypoxia.